chromatin remodeling by hswi/snf atp-dependent complexes
| PAG Title | chromatin remodeling by hswi/snf atp-dependent complexes |
| PAG ID | WAG000249 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The eukaryotic genome is packaged by histone and nonhistone proteins to form chromatin. The assembly of nucleosomesas well as compaction of nucleosomal arrays into higher-order chromatin structures create a highly restrictive environment for nuclear processes that require access to D. The packaging of eukaryotic D into nucleosomes inhibits the access of factors to D and thus results in the repression of transcription, replication,and recombition. To counterbalance the repressive ture of chromatin, a variety of chromatin remodeling factors use the energy of ATP hydrolysis to facilitate the interaction of proteins with nucleosomal D. ATP dependent chromatin remodeling complexes are characterized by the presence of an ATPase subunit from SNF2-like family of the DEAD/H (SF2) D-stimulated ATP-ases. The highly conservative hSWI/SNF multisubunit complexes contain hBRM or BRG1 ATPases which alter the histone-D contacts ebling the access of general transcription factors to promoter regions. Remodeling complexes are targeted to promoters via interactions with sequence-specific transcription factors. |
| Species | Homo sapiens |
| nCoCo Score | 6,828 |
| Base PAG ID | WAG000249 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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